Interaction of the Chiral Forms of Ketamine with Opioid, Phencyclidine, σ and Muscarinic Receptors

In order to elucidate the mechanisms of action of ketamine, we have investigated the binding of the chiral forms of ketamine to opioid (μ, δ and κ), phencyclidine, σ and muscarinic receptors and we have performed detailed concentrati...

Olav，Hustveit，Atle，... - 《Pharmacology & Toxicology》

Pharmacokinetics and analgesic effects of i.m. and oral ketamine.

The pharmacokinetics and analgesic effects of i.m. and oral ketamine in a dose of 0.5mgkg were determined in six healthy volunteers. Analgesia was measured by the tubmazimal effort tourniquet test. Following both mutes of administration,...

GRANT I. S.，NIMMO W. S.，CLEMENTS J. A. - 《British Journal of Anaesthesia》

The n-of-1 Randomized Controlled Trial: Clinical Usefulness: Our Three-Year Experience

To review the feasibility and effectiveness of n-of-1 randomized controlled trials (n-of-1 trials) in clinical practice. Individual trials were double-blin...

GH Guyatt，JL Keller，R Jaeschke，... - 《Annals of Internal Medicine》

The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input

Hyperactivity of N -methyl d -aspartate (NMDA) receptors may be one of the factors in the maintenance of persistent stump and phantom limb pain. Ketamine (...

L Nikolajsen，CL Hansen，J Nielsen，... - 《Pain》

Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.

Hyperactivity of N-methyl-d-aspartate (NMDA) receptors may be one of the factors in the genesis of neuropathic pain. Ketamine is an NMDA-blocking agent wid...

M Backonja，G Arndt，KA Gombar，... - 《Pain》

Lack of effect of ketamine analgesia on gastric emptying in man

The effect of ketamine analgesia on gastric emptying was assessed in five healthy volunteers. Gastric emptying, estimated indirectly by the absorption of orally administered paracetamol, was not significantly delayed following administra...

GRANT I. S.，NIMMO W. S.，CLEMENTS J. A. - 《Br J Anaesth》

Ketamine injection used orally.

Ketamine has been used parenterally for pain unresponsive to opioids, including neuropathic pain, and has also been used as an alternative analgesic agent ...

K，E，Broadley，... - 《Palliative Medicine》

Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia.

The effect of continuous subcutaneous (s.c.) infusion of ketamine on nerve injury pain was examined in patients with post-herpetic neuralgia. Five patients...

K Eide，A Stubhaug，I Oye，... - 《Pain》

A clinician's guide for conducting randomized trials in individual patients

In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a par...

G.H. Guyatt，D. L. Sackett，J. D. Adachi，... - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design.

The aim was to compare the analgesic effectiveness and adverse effect incidence of oral dextromethorphan (DM) with placebo in patients with neuropathic pai...

HJ Mcquay，D Carroll，AR Jadad，... - 《Pain》