To determine if p.R47H (rs75932628) in is a risk factor for ALS and assess whether expression is dysregulated in disease.Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which microglia play a significant and a...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which microglia play a significant and active role. Recently, a rare missense v...
Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of pathogens, regulation of the inflammatory milieu, and mediation...
BACKGROUND AND OBJECTIVE: Periodontitis is an infectious disease in which the host immune and inflammatory responses play essential roles in resistance to ...
MicroRNAs (miRNAs) have recently found to be dysregulated in serum from multiple sclerosis (MS) patients. Cell free circulating miR-15b, -23a and 223 levels were analyzed by Real Time PCR in a cohort consisting of 30 serum samples from R...
Over activation of conventional dendritic cells (cDCs) contributes to the development of systemic lupus erythematosus (SLE). Triggering receptor expressed ...
Purpose : Topical glaucoma drugs are associated with a high prevalence of Ocular Surface Disease (OSD), significantly affecting patient adherence. Clinical...
Background Alzheimer's disease (AD) is a neurodegenerative disease associated with neuroinflammation, dysregulated neurovascular coupling, abnormal neuroplasticity, and neuropathological makers, including tau and 尾-amyloid deposition. A...
Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role for microglia in the pathogenesis of AD. The majorit...
Variants ofare associated with Alzheimer’s disease (AD). To study whether increasinggene dosage could modify the disease pathogenesis, we developed B...
Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully und...
The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a centur...
Minimotifs are modular contiguous peptide sequences in proteins that are important for posttrans- lational modifications, binding to other molecules, and t...
Minimotifs are modular contiguous peptide sequences in proteins that are important for posttrans- lational modifications, binding to other molecules, and t...
BackgroundThe R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimerȁ...
diabetes exhibited a significantly higher risk of developing AD than age-matched subjects without T2DM (Leibson et al., 1997; Huang et al., 2014). Epidemiological studies have also examined the association between ApoE4 genotype and diab...
