COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR H<SB>3</SB>AND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATION OF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS
申请(专利)号：
EP04767475.9
申请日期：
20040625
公开/公告号：
EP1641461A1
公开/公告日期：
20060405
申请(专利权)人：
BIOPROJET
国省代号：
FR
被引量：
摘要：
The invention relates to a medicament which comprises, in a pharmaceutically-acceptable vehicle, an antipsychotic agent or an antidepressant agent (A), the only adverse effect thereof being weight gain or sedation, and an antagonist and/or inverse agonist (B) of histamine receptor H3, said antagonist and/or inverse agonist of histamine receptor H3 being present in a therapeutically-effective quantity such as to provide at least one of the following three effects: suppression or at least limitation of the adverse weight gain effect, suppression or limitation of the adverse effect on vigilance, epilepsy/convulsions, increase in the pro-cognitive effect of the treatment. The invention also relates to one such antagonist or inverse agonist for the preparation of a medicament that is intended to provide at least one of the aforementioned effects in a patient being treated with one such antipsychotic or antidepressant agent
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