Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
The tobacco-specific carcinogens, N'-nitrosonornicotine (NNN) and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), were tested for carcinogenicity in F344 rats. Each nitrosamine in trioctanoin was administered by s.c. injection...
SS Hecht，CB Chen，T Ohmori，... - 《Cancer Research》
Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities
Since 1940s, Quinoxaline 1,4-dioxides (QdNO's) are known as potent antibacterial agents, and subtherapeutic levels have been used to promote growth and imp...
A. Carta, P. Corona, M. Loriga - 《Current Medicinal Chemistry》
Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide
Quinoxaline 1,4-dioxide () is the historical prototype for modern heterocyclic -oxide antitumor agents such as 3-amino-1,2,4-benzotriazine 1,4-dioxide (tir...
B Ganley，G Chowdhury，J Bhansali，... - 《Bioorg Med Chem》
Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides.
The quinoxaline-di-N-oxides carbadox, olaquindox, and quindoxin, which are potent antibacterial agents, were tested for mutagenicity in the Salmonella microsomal system. They all induced base pair substitutions and frameshift mutations i...
L Beutin，E Preller，B Kowalski - 《Antimicrobial Agents & Chemotherapy》
Health risks associated with inhaled nasal toxicants.
Health risks of inhaled nasal toxicants were reviewed with emphasis on chemically induced nasal lesions in humans, sensory irritation, olfactory and trigem...
V，J，Feron，... - 《Critical Reviews in Toxicology》
Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities
Since 1940s, Quinoxaline 1,4-dioxides (QdNO's) are known as potent antibacterial agents, and subtherapeutic levels have been used to promote growth and imp...
A Carta，P Corona，M Loriga - 《Current Medicinal Chemistry》
喹噁啉-1,4-二氧化物类抗菌促生长剂特殊毒理学研究进展
喹口恶 啉 - 1 ,4-二氧化物取代衍生物卡巴氧,喹乙醇,西吖氧作为抗菌促生长饲料添加剂广泛应用于猪.为了评价它们的安全性 ,本文从致突变,致癌性和生殖毒性三方面对它们...
曹随忠，张力，梁剑平，... - 《动物医学进展》
Acute and subchronic toxicological evaluation of Mequindox in Wistar rats
We studied an acute and subchronic oral toxicity of Mequindox (MEQ), a quinoxaline 1,4-dioxide antimicrobial promoter, in Wistar rats according to OECD gui...
A Ihsan，X Wang，XJ Huang，... - 《Regulatory Toxicology & Pharmacology》
Experimental induction of renal tumors.
Renal tumors have been reported to be induced by natural products, chemical carcinogens, viruses, or radiation. Species or strain specificity and sex also ...
Y Hiasa，N Ito，P Bannasch，... - 《Critical Reviews in Toxicology》
DNA damage induced by a quinoxaline 1,4-di-N-oxide derivative (hypoxic selective agent) in Caco-2 cells evaluated by the comet assay
The DNA damage induced by 7-chloro-3-[[(N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride (Q-85 HCl) in Caco-2 cells u...
A Amaia，P Gisela，C Marta，... - 《Mutagenesis》
