Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

PLX4032/vemurafenib is a first-in-class small-molecule BRAFV600E inhibitor with clinical activity in patients with BRAF mutant melanoma. Nevertheless, drug...

E Vergani，V Vallacchi，S Frigerio，... - 《Neoplasia》

Identification of \\{MET\\} and \\{SRC\\} Activation in Melanoma Cell Lines Showing Primary Resistance to \\{PLX4032\\}

PLX4032/vemurafenib is a first-in-class small-molecule BRAF^V600E inhibitor with clinical activity in patients with BRAF mutant melanoma. Neverth...

Elisabetta，Vergani，Viviana，... - 《Neoplasia》

Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells

Metastasis-associated phosphatase of regenerating liver-3 (PRL-3) has pleiotropic effects in driving cancer progression, yet the signaling mechanisms of PR...

AQO Al-Aidaroos，HF Yuen，K Guo，... - 《Journal of Clinical Investigation》

Modulation of arsenic-induced epidermal growth factor receptor pathway signalling by resveratrol

Arsenic (As) is both a human carcinogen and an effective anticancer drug. These aspects of arsenic toxicity develop as a consequence of arsenic-induced oxi...

KJ Herbert，ET Snow - Chemico-Biological Interactions

Application of MM-GB/SA and WaterMap to SRC Kinase Inhibitor Potency Prediction

WaterMap and MM-GB/SA scoring methods were applied to an extensive congeneric series of small-molecule SRC inhibitors with high-quality enzyme data and wel...

A Kohlmann，X Zhu，D Dalgarno - 《Acs Medicinal Chemistry Letters》

SRC points the way to biomarkers and chemotherapeutic targets.

The role of Src in tumorigenesis has been extensively studied since the work of Peyton Rous over a hundred years ago. Src is a non-receptor tyrosine kinase...

H Krishnan，WT Miller，GS Goldberg - 《Genes Cancer》

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein

The Src family tyrosine kinases (SFK) are cellular regulatory proteins that influence cell adhesion, proliferation, invasion and survival during tumor deve...

A Szalmás，E Gy?Ngy?Si，A Ferenczi，... - 《Virology Journal》

Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells

Top of pageIntroduction Materials and Methods Results Discussion Acknowledgments Conflict of Interest References Iron is required for cellular proliferatio...

G Siriwardana，PA Seligman - 《Physiological Reports》

HPV检测在宫颈病变进展中的研究进展

宫颈癌是常见的妇产科恶性肿瘤,该病的发病率位居女性恶性肿瘤第二,尽早发现与及时采取有效治疗措施有助于保护患者的身体健康,且对挽救生命也具有重要意义[1-2].有关资...

侯素平，张凤芹，张宪军，... - 《国际检验医学杂志》

Abstract 5869: Resistance mechanism against trastuzumab in HER2-positive cancer cells and its negation by Src inhibition

Background: In biliary tract cancer (BTC), no molecular therapeutic target has been validated so far. Therefore, cytotoxic chemotherapy is the mainstay of treatment of advanced BTC and the prognosis is poor and there is a huge unmet medi...

M Jin，AR Nam，EP Ji，... - 《Cancer Research》