Microreservoir liposome composition and method

A liposome composition for extended release of a therapeutic compound into the bloodstream. The liposomes are composed of vesicle- forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic polym...

FJ Martin，MC Woodle，C Redemann，... - US

Stable plurilamellar vesicles, their preparation and use

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same. SPLVs are stable during storage and can be used in vivo for the sustained re...

RP Lenk，MW Fountain，AS Janoff，... - US

Method of preparing a controlled-release pharmaceutical preparation, and resulting composition

A method of preparing a controlled-release pharmaceutical compound for oral administration, which pharmaceutical compound is subject to enzymatic hydrolysis on oral administration, which method comprises encapsulating the pharmaceutical ...

BD Sears - US

Treatments employing drug-containing matrices for introduction into cellular lesion areas

Treatment of cellular disorders involving abnormal solid cellular growths involves introduction of cytotoxic reagents dispersed in a physiologically acceptable proteinaceous matrix into the solid cellular growth or area of an existing or...

EE Luck，DM Brown - US

Occipitocervical plate

Methods and systems for occipital-cervical spinal fixation. A plate configured for attachment to the occipital bone has two arms extending out from either side, which turn downwards parallel to one another. A first bend is disposed in th...

DL Brockmeyer，N Avery

Process for the preparation of liposomes in aqueous solution

A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula ...

M Schneider - US

Large unilamellar vesicles (LUV) and method of preparing same

A process and resulting product for producing large unilamellar phosphatidylserine vesicles (LUV) in the diameter of about 2, 000-12,000 A which may additionally encapsulate a drug. The large vesicles are prepared from an initial phospha...

PD Papahadjopoulos

Liposome composition and production thereof

The liposome compositions entrapping a drug are prepared by constituting the liposomal membrane with a saturated phospholipid and a glycolipid having sialic acid group. Thus obtained compositions circulate stably in blood for a long time...

K Iga，N Hamaguchi，Y Ogawa - CA

ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSOMES.

methods are described for encapsulating ionizable antineoplastic agents with the help of transmembrane potentials. we soon got yields close to 100% of entrapment and loading easier. in addition we describe protocols for the practical use...

BALLY MARCEL B.，CULLIS PIETER R.，HOPE MICHAEL J.，...

Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species

Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating...

JD Baldeschwieler，RC Gamble，MR Mauk - US