ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSOMES.
申请(专利)号：
WO1985US01501
申请日期：
1985-08-07
公开/公告号：
WO8601102A1
公开/公告日期：
1986-02-27
申请(专利权)人：
THE LIPOSOME COMPANY, INC.
被引量：
摘要：
methods are described for encapsulating ionizable antineoplastic agents with the help of transmembrane potentials. we soon got yields close to 100% of entrapment and loading easier. in addition we describe protocols for the practical use of dehydrated liposomes for administration of antineoplastic agents in a clinical setting.according to other aspects of the invention, the transmembrane potentials are used to reduce the rate of release of ionizable drugs contained in liposomes.
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