On the Relationship between the Chemical Structure and the Cyclic AMP Phosphodiesterase Inhibitory Activity of Flavonoids as Studied by 13C NMR

The relationship between the chemical structure and the cyclic adenosine monophosphate phosphodiesterase inhibitory activity was studied regarding forty-ei...

Y Sakamoto，T Ohmoto，T Nikaido，... - 《Bull.chem.soc.jpn》

Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices

D. G.;Loew, G.;Kmg, R.; Mansour, J. M.; Mansour, T. E.; Structure/Activity Studies of Flavonoids as Inhibitors of Cyclic AMP Phosphodiesterase and Relationship to Quantum Chemical Indices. Mol. Pharmacol. 1979, 16, 556-568....

JE Ferrell，PDC Sing，G Loew，... - 《Molecular Pharmacology》

Cyclic Adenosine Monophosphate and Alteration of Chinese Hamster Ovary Cell Morphology: a Rapid, Sensitive In Vitro Assay for the Enterotoxins of Vibrio ch...

The major limitation to our understanding of the clinical importance of enterotoxigenic Escherichia coli in diarrheal illness has been the lack of a simple...

RL Guerrant，LL Brunton，TC Schnaitman，... - 《Infection & Immunity》

Inhibition of lung cyclic AMP- and cyclic GMP-phosphodiesterases by flavonoids and other chromone-like compounds

A series of 17 flavonoids and related compounds were tested as inhibitors of bovine lung cyclic AMP- and cyclic GMP-phosphodiesterase, comparatively to 12 reference substances, including antianaphylactic drugs. Most of the chromone-like ...

M Ruckstuhl，Y Landry - 《Biochemical Pharmacology》

Phosphodiesterase-4 as a potential drug target

Structure-Activity Relationship3',5'-Cyclic-AMP PhosphodiesterasesCyclic Nucleotide Phosphodiesterases, Type 4Phosphodiesterase-4 (PDE4) is the predominant ...

KY Zhang，PN Ibrahim，S Gillette，... - 《Expert Opinion on Therapeutic Targets》

SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE

This invention is directed to physiologically active compounds of formula (I) wherein (i) represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring (ii) is an azaheterocycle, and the ring (iii) represents...

COX Paul Joseph，BOWER Shelley，ALDOUS David John，... - CA

Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity

WO/1994/002465 February, 1994 INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF WO/1994/010118 May, 1994 TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION WO/1994/012461 June, 1994 CATECHOL DIETHERS AS SELECTIVE PDEIV IN...

M Chasin，D Cavalla，P Hofer - EP

Inhibitors of Cyclic AMP Phosphodiesterase in Picrasma quassioides BENNET, and Inhibitory Activities of Related β-Carboline Alkaloids

Cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitors present in Picrasma quassioides BENN. were identified as 1-methoxycarbonyl-β-carboline,...

S Yeolik，小池 一男，二階堂 保，... - 《Chemical & Pharmaceutical Bulletin》

Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells

The role of non-calcineurin protein phosphatases in the cyclic AMP signal transduction pathway was examined in mouse pituitary corticotroph tumour (AtT20) ...

A Antaraki，KL Ang，FA Antoni - 《British Journal of Pharmacology》