Advanced Textbook. (Book Reviews: Stereochemistry of Carbon Compounds)

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EL Eliel - 《Science》

ML-236B Derivatives and their preparation

Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C. sub.5 alkyl esters) thereof may be ...

A Terahara，M Tanaka - US

Stereochemistry of Carbon Compounds

The purpose of this paper is to present an assessment and evaluation model for the prioritization of distributed generation (DG) technologies, both convent...

W Klyne - Science Progress (1933- )

MERRELL DOW PHARMACEUTICALS INC'S (TERFENADINE) PATENT

Patent — Licence of right — Terfenadine — Application for settlement of terms — Practice — Evidence of other supply agreements — Discovery — Patentees' appeal dismissed — Applicants' cross-appeal allowed in part.Office practice ...

P Court - 《Reports of Patent Design & Trade Mark Cases》

Farnesyl protein transferase inhibiting (imidazol-5-yl) methyl-2-quinolinone derivatives

This invention comprises the novel compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R 1 is hydrogen, C 1-12 alkyl, Ar 1 , Ar 2 C 1-6 alkyl, quinolinylC 1-6 alkyl, pyridylC 1-6 alkyl, h...

MG Venet，PR Angibaud，P Muller，... - US

Chapter 18. Ras Farnesyltransferase Inhibitors

The ras proteins have been the subject of intense research in recent times, and comprehensive reviews of their structural properties and biochemical function have appeared. Mutant ras oncogenes are found in approximately 25% of all human...

S Ayral-Kaloustian，JS Skotnicki - 《Annual Reports in Medicinal Chemistry》

Heterozyklische Farnesyl-Protein-Transferase-Inhibitoren

The ras proteins have been the subject of intense research in recent times, and comprehensive reviews of their structural properties and biochemical function have appeared. Mutant ras oncogenes are found in approximately 25% of all human...

DV Patel，Toni Kline，CA Meyers，...

Inhibitors of prenyl transferases

Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.

S Sebti，A Hamilton

New inhibitors of poly(ADP-ribose) polymerase (PARP)

Poly(ADP-ribose) polymerase-1 (PARP-1), the most prominent member of the PARP family, is a DNA-binding protein that is activated by nicks in DNA occurring ...

S Peukert，U Schwahn - 《Expert Opinion on Therapeutic Patents》

Farnesyl transferase inhibitors

A family of tetrahydroimidazo[1,2a]pyrazine based compounds capable of inhibiting the activity of farnesyl transferase and treating tumors and restenosis having the following structure: or a pharmaceutically acceptable salt thereof, wh...

Thomas D. Gordon，Barry A. Morgan