A peptide antibiotic from human skin.
摘要：
To avoid opportunistic infections, plants and animals have developed antimicrobial peptides in their epithelia that can form pores in the cytoplasmic membrane of microorganisms. After contact with microorganisms, vertebrate skin, trachea and tongue epithelia are rich sources of peptide antibiotics, which may explain the unexpected resistance of these tissues to infection. Here we report that human skin is protected in a similar way by an inducible, transcriptionally regulated, antibiotic peptide, which resembles those in other mammals.
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关键词：
Humans Escherichia coli Psoriasis Peptides beta-Defensins Proteins Blood Proteins Anti-Bacterial Agents Microbial Sensitivity Tests Cloning, Molecular
DOI：
10.1038/43088
被引量：
年份：
1997
Taylor & Francis
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掌桥科研
万方医学
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