Representing and understanding the three-dimensional (3D) structural information of protein−ligand complexes is a critical step in the rational drug dis...
Composition and gene content of a biogas-producing microbial community from a production-scale biogas plant fed with renewable primary products was analyse...
The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing hig...
The rational design of protein structure and function is rapidly emerging as a powerful approach to test general theories in protein chemistry (1). De novo...
We disclose herein the rapid discovery of the first highly potent (Ki = 7.7 nM) non-nucleoside adenosine deaminase (ADA) inhibitor based on the rational hy...
The present work is devoted to the preparation of Ag/TiO2 nanosystems by an original synthetic strategy, based on the radio-frequency (RF) sputtering of si...
Ironing out the details: Proline and pyrrolidine derivatives (Hayashi Jrgensen catalysts) are considered work horses in organocatalysis. This report descri...
In order to minimise attrition rates in drug development projects, a target discovery process is implemented to select and characterise the most suitable c...
Background Recently, a number of large-scale cancer genome sequencing projects have generated a large volume of somatic mutations; however, identifying the...
The "international community" presented an apparent unanimity in its endorsement of prohibitive drug control at the United Nations General Assembly Special...
Disopyramide is a new antiarrhythmic drug with a pharmacological profile of action similar to that of quinidine and procainamide. In a few controlled thera...
Synopsis: Tamoxifen1is a triphenylethylene oestrogen antagonist which has partial oestrogen agonist activity in some species. Most therapeutic trials with ...
We discuss the biochemical and cellular properties of ACAT in detail in liver and the intestine. We also briefly consider these topics in steroid hormone-producing tissue and in arterial tissue in an attempt to relate the function of ACA...
Synopsis: Probucol 1 is a cholesterol-lowering drug without structural similarities to other lipid-lowering agents. It reduces serum cholesterol levels by...
The cardiotonic activity of milrinone (Win 47203), a potent analogue of amrinone, was demonstrated in isolated guinea pig, cat, rabbit, rat, and hamster at...
The cardiotonic activity of milrinone (Win 47203), a potent analogue of amrinone, was demonstrated in isolated guinea pig, cat, rabbit, rat, and hamster at...
IN earlier communicationstwo of us have described the œstrogenic activity of certain derivatives of diphenylethane, and in particular it was shown that the introduction of an ethylene linkage between the α and β carbon-atoms of such...
IN earlier communicationstwo of us have described the œstrogenic activity of certain derivatives of diphenylethane, and in particular it was shown that the introduction of an ethylene linkage between the α and β carbon-atoms of such...
Two types of aromatic amides, terephthalic monoanilides and (arylcarboxamido)benzoic acids, have been shown to possess potent retinoidal activities and can...
