Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients.

The performances of schizophrenic patients and normal control subjects were compared on an extensive battery of psychological tests that have been found at the Montreal Neurological Hospital to be differentially sensitive to lesions of t...

B Kolb，IQ Whishaw - 《Journal of Nervous & Mental Disease》

Ethanol inhibits NMDA-activated ion current in hippocampal neurons.

The ion current induced by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH...

D Lovinger，G White，F Weight - 《Science》

Observations on the brains of non-demented old people

The pathological findings in the brains of 28 old people, established by careful examination shortly before death as being free of evidence of dementia, ar...

BE Tomlinson，G Blessed，M Roth - 《Journal of the Neurological Sciences》

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from their ability to antagonize the excitotoxic actions of endogen...

J Olney，J Labruyere，M Price - 《Science》

Word fluency and brain damage

A group of sixty-six adult subjects was given the task of producing as many words as possible beginning with specified letters of the alphabet. The number ...

JG Borkowski，AL Benton，O Spreen - 《Neuropsychologia》

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

In the cerebrospinal fluid of 20 schizophrenic patients the glutamate level was found to be about half the normal value, whereas the serum glutamate was no...

JS Kim，HH Kornhuber，W Schmid-Burgk，... - 《Neuroscience Letters》

The risks and benefits of clozapine versus chlorpromazine.

Clozapine is an atypical antipsychotic drug with reduced risk of unwanted neurological effects in comparison with other drugs. In this multicenter study, 151 hospitalized schizophrenic patients were randomly assigned to treatment under d...

J Claghorn，G Honigfeld，FS Abuzzahab，... - 《J.clin.psychopharmacol》

Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates

In a large number (91) of vervet monkeys, correlation coefficients were determined between homovanillic acid (HVA) concentrations in four brain areas. Sign...

JD Elsworth，DJ Leahy，RH Roth，... - 《Journal of Neural Transmission》

-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

It has been proposed that three major receptor subtypes subserve the putative transmitter role of glutamate and aspartate in the mammalian central nervous ...

AM Thomson，DC West，D Lodge - 《Nature》

Psychedelic Experiences in Acute Psychoses

The disease which thus evokes these new and wonderful talents and operations of the mind may be compared to an earthquake which, by convulsing the upper st...

MB Bowers，DX Freedman - 《Archives of General Psychiatry》