Function and the Evolution of Phenotypic Stability: Connecting Pattern to Process

This paper explores the role of functional integration and functional trade-offs in generating phenotypic stability by limiting the responses of individual ...

K Schwenk，GP Wagner - 《Amer Zool》

Function and the Evolution of Phenotypic Stability: Connecting Pattern to Process1

Phenotypes manifest a balance between the inherited tendency to remain the same (phenotypic stability) and the tendency to change in response to current en...

K Schwenk，GP Wagner - 《American Zoologist》

Functional studies of rare CFTR missense mutations facilitate interpretation of genotype-phenotype relationships.

Cystic Fibrosis (CF) is a common, life-limiting autosomal recessive disorder caused by a mutation in the Cystic Fibrosis Transmembrane Conductance Regulato...

KV Krasnov - The Johns Hopkins University.

The structural basis of protein targeting and translocation in bacteria

In Gram-negative bacteria, two distinct targeting routes assist in the proper localization of secreted and membrane proteins. Signal recognition particle (...

AJM Driessen，EH Manting，CVD Does - 《Nature Structural Biology》

Use of molecular genetics for understanding seabird evolution, ecology and conservation

Information on genetic variation within and among populations of highly mobile organisms such as seabirds is necessary for understanding their evolution an...

SA Taylor，VL Friesen - 《Marine Ecology Progress》

Modulation of chromatin by MARs and MAR binding oncogenic transcription factor SMAR1.

The orchestration of the events in the cell during the progression of the cell cycle is modulated by various phenomenon which are regulated by structural m...

KK Nakka，S Chattopadhyay - 《Molecular & Cellular Biochemistry》

Gamma secretase notch biomarkers

The present invention relates to the biomarker TFF-3 that measures 纬-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determini...

R Denton，JE Meredith

Methods of producing and growing plants having improved phosphorus utilization

The invention discloses methods for genetically transforming a plant so that it expresses a glycerol-3-phosphate dehydrogenase. The method raises levels gl...

J Zou，W Shen，W Keller