Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death
摘要：
2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death.
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关键词：
DCG-IV ((2 S ,1′ R ,2′ R ,3′ R )-2-(2,3-dicarboxycyclopropyl)glycine Excitotoxicity Metabotropic glutamate receptor Cortical neuron
DOI：
10.1016/0014-2999(94)90624-6
被引量：
年份：
1994
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