Cell-Independent Fabrication of Tissue Equivalents
申请(专利)号：
WO2005GB02631
申请日期：
2005-07-05
公开/公告号：
WO2006003442A2
公开/公告日期：
2006-01-12
申请(专利权)人：
UCL BUSINESS PLC;BROWN, ROBERT;NAZHAT, SHOWAN;MUDERA, VIVEK;WISEMAN, MIKE
被引量：
摘要：
This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organised biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibres of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
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