Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.
阅读量：
112
摘要：
We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seen occasionally. This implies that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells. These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.
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关键词：
Animals Humans Cells, Cultured Chromosomes, Human, Pair 12 Chromosome Aberrations Aneuploidy Karyotyping Cell Culture Techniques Specimen Handling Cell Differentiation
DOI：
10.1038/nbt922
被引量：
年份：
2004
Nature
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万方医学
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