Phagocyte recognition of cells undergoing apoptosis

A key feature of apoptosis is that cells undergoing this programmed form of death are recognized by phagocytes and ingested while still intact, protecting tissues from the potentially harmful consequences of exposure to the contents of t...

J Savill，V Fadok，P Henson，... - 《Immunology Today》

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

The binding of affinity-purified anticardiolipin antibodies (ACA) to liposomes that contained cardiolipin or phosphatidylserine was investigated. ACA bound...

M Galli，T Barbui，P Comfurius，... - 《Lancet》

Antiphospholipid antibodies are directed against a complex antigen which includes a lipid-binding plasma glycoprotein

Study to define the contribution of the Tryptase family of serine proteases in the mast cells pathogenic role in the development of chronic kidney disease.

H Mcneil，C Chesterman，S Krilis - 《Clinical & Experimental Rheumatology》

Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine

Apoptosis of vascular smooth muscle cells has recently been demonstrated to occur in vitro and in vivo. Uptake of apoptotic cells into adjacent normal cell...

MR Bennett，DF Gibson，SM Schwartz，... - 《Circulation Research》

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

During the past 20 years contributions from many laboratories have led to the development of isolation procedures, delineation of primary structures, and m...

KG Mann，ME Nesheim，WR Church，... - 《Blood》

Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus er...

The restriction of phosphatidylserine (PtdSer) to the inner surface of the plasma membrane bilayer is lost early during apoptosis. Since PtdSer is a potent...

L Casciola-Rosen，A Rosen，M Petri，... - 《Proc Natl Acad Sci U S A》

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

One of the key features associated with in many tissues is the of apoptotic bodies by macrophages. Removal of apoptotic cells occurs before their lysis, indicating that these cells, during the of , express specific surface changes recogn...

VA Fadok，JS Savill，C Haslett，... - 《Journal of Immunology》

Changes in membrane phospholipid distribution during platelet activation

(1) Exposure of phospholipids at the outer surface of activated and control platelets was studied by incubation with a mixture of phospholipase A2 from Naj...

EM Bevers，P Comfurius，RFA Zwaal - Biochimica et Biophysica Acta (BBA) - Biomembranes

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids

The specific recognition of anionic phospholipids in the outer leaflets of cell membranes and lipoproteins by cell surface receptors may play an important ...

A Rigotti，SL Acton，M Krieger - 《Journal of Biological Chemistry》

Generation of Prothrombin-Converting Activity and the Exposure of Phosphatidylserine at the Outer Surface of Platelets

In the present paper we compare prothrombin-converting activities of platelets non-activated, or activated by collagen, thrombin or collagen plus thrombin ...

EM Bevers，P Comfurius，JLMLV Rijn，... - 《European Journal of Biochemistry》