N-terminally chemically modified protein compositions and methods

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel...

OB Kinstler，NE Gabriel，CE Farrar，... - US

Enzyme immobilization with pullulan gel

Enzymes are immobilized by a process wherein the carrier used for immobilizing is a hydrophilic pullulan gel having a three-dimensionally reticulated structure obtained by the reaction between pullulan and a bifunctional compound capable...

H Hirohara，S Nabeshima，M Fujimoto，... - US

Immunoglobin-like domains with increased half lives

Enzymes are immobilized by a process wherein the carrier used for immobilizing is a hydrophilic pullulan gel having a three-dimensionally reticulated structure obtained by the reaction between pullulan and a bifunctional compound capable...

WE Sally

Preparation of an activated polymer ester for protein conjugation

The present invention is a process for preparing an activated ester of polyethylene glycol or a polyoxyethylated polyol. After the activated ester is prepared, it can be reacted with a protein to form a polymer/protein conjugate. Conjug...

DE Nitecki - US

Polyethylene-protein conjugates

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of ...

J Hakimi，P Kilian，P Rosen - US

Hybrid immunoglobulins

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of ...

 - US

Altered polypeptides with increased half-life

Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulato...

Brevet US Altered polypeptides with increased halflife - US

Preparation of a polymer/interleukin-2 conjugate

The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjug...

DE Nitecki，Katre, Nandini Goodson Robert J.，L Aldwin - US

Porous bearing system having internal grooves and electric motor provided with the same

An improved porous bearing and a motor which is provided with the porous bearing in which the friction losses and reflection of shaft are reduced, noises caused by the vibrations are avoided with low cogging or low jitter, and in additio...

M Miyasaka，M Kondo，S Otsuka - US

Peptide library and screening method

A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA bind...

PJ Schatz，MG Cull，JF Miller，... - EP