ChemInform Abstract: Organometallic Derivatives of Hormonal Steroids: 500㎝Hz Oneand TwoDimensional NMR Spectra of 17α㏄ropynylestra3,5(10)‐triene17βdiol and Its Co2(CO)6 and (C5H5)2Mo2(CO)4 Complexes
摘要：
Treatment of estrone with a propynyl Grignard reagent gives exclusively 17α-propynylestra-1,3,5(10)-triene-3,17β-diol. This 17α-alkynyl steroid reacts with Co2(CO)8 or (C6H5)2Mo2(CO)4 to yield the cluster complexes (RC≡CR′)M2, where R = methyl, R′ is the steroidal moiety, and M = Co(CO)3 or (C5H5)Mo(CO)2. The cobalt complex of mestranol has likewise been prepared. The 500-MHz 1H NMR spectra of these molecules are reported and are assigned by the two-dimensional COSY technique. The shifts of the 12α- and 14α-protons of the steroid are discussed in terms of the anisotropy in diamagnetic susceptibility of the alkyne linkage. 13C spectra are also reported.
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DOI：
10.1002/chin.198701291
被引量：
年份：
1987
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