Mechanism of action of antiinflammatory drugs.
摘要：
Among the many mediators of inflammation, the prostaglandins (PGs) are of great importance. They are released by almost any type of chemical or mechanical stimulus. The key enzyme in their synthesis is prostaglandin endoperoxide synthase (PGHS) or cyclooxygenase (COX) which possesses two catalytic sites. The first, a cyclooxygenase active site, converts arachidonic acid to the endoperoxide PGG 2 . The second, a peroxidase active site, then converts the PGG 2 to another endoperoxide PGH 2 . PGH 2 is further processed by specific isomerases to form PGs, prostacyclin and thromboxane A 2 . Of the PGs, PGE 2 and prostacyclin are the main inflammatory mediators. Cyclooxygenase activity has long been studied in preparations from sheep seminal vesicles and a purified, enzymatically-active COX was isolated in 1976 1 . We now know that COX exists in at least two isoforms, COX-1 and COX-2.
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关键词：
Animals Humans Gold Inflammation Histamine Salicylates Colchicine Bradykinin Arachidonic Acids Platelet Activating Factor
DOI：
10.1007/978-94-011-4872-6_1
被引量：
年份：
1998
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