Contrasting properties of two forms of long-term potentiation in the hippocampus

Activity-dependent enhancement of synaptic transmission, referred to as long-term potentiation (LTP), is observed at many synapses in the central nervous s...

RA Nicoll，RC Malenka - 《Nature》

The role of Rab3A in neurotransmitter release

THE small GTP-binding protein Rab3A is a Rab family member 1–3 that is abundant in brain synaptic vesicles 4,5 . Here we show that mice in which the rab3...

M Geppert，VY Bolshakov，SA Siegelbaum，... - 《Nature》

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

The Rab family of low-molecular-mass GTP-binding proteins are thought to guide membrane fusion between a transport vesicle and the target membrane, and to ...

M Geppert，Y Goda，CF Stevens，... - 《Nature》

cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis

Behavioral sensitization leads to both short- and long-term enhancement of synaptic transmission between the sensory and motor neurons of the gill-withdrawal reflex in Aplysia. Serotonin (5-HT), a transmitter important for short-term sen...

S Schacher，V Castellucci，E Kandel - 《Science》

Distinct short-term plasticity at two excitatory synapses in the hippocampus.

A single mossy fiber input contains several release sites and is located on the proximal portion of the apical dendrite of CA3 neurons. It is, therefore, w...

PA Salin，M Scanziani，RC Malenka，... - 《Proceedings of the National Academy of Sciences of the United States of America》

The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse

The mossy fiber synapse between dentate granule cells and CA3 pyramidal cells in the guinea pig hippocampus shows a robust short-term synaptic enhancement....

Regehr, WG，Delaney, KR，Tank, DW - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》

Distinct short-term plasticity at two excitatory synapses in the hippocampus

The mossy fiber synapse between dentate granule cells and CA3 pyramidal cells in the guinea pig hippocampus shows a robust short-term synaptic enhancement....

Paul A. Salin，Massimo Scanziani，Robert C. Malenka，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Long-term potentiation in mice lacking synapsins

Synapsin I and synapsin II are widely expressed synaptic vesicle phosphoproteins that have been proposed to play an important role in synaptic transmission...

DM Spillane，TW Rosahl，TC Südhof，... - 《Neuropharmacology》

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice d...

M Yokoi，K Kobayashi，T Manabe，... - 《Science》

Quantal mechanism of long-term synaptic potentiation

Intracellular recordings were used to demonstrate the occurrence and to analyze the microphysiology of long-term synaptic potentiation (LTP) in the crayfis...

DA Baxter，GD Bittner，TH Brown - 《Proceedings of the National Academy of Sciences of the United States of America》