Antihypercholesterolemic compounds
6(R)- 2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)- polyhydronaphthyl-1')-ethyl!-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-p yran-2- ones are prepared by acylation of the corresponding 8'-hydroxy compounds. The products are strong inhibitor...
WF Hoffman，RL Smith，AK Willard - US
Idene analogs of mevalonolactone and derivatives thereof
Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions ...
FG Kathawala，Sompong Wattanasin - US
Isoxazolyl endothelin antagonists
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-...
N Murugesan，JC Barrish，Z Gu，... - US
Diabetes
Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1(7-36) have been found to have insulinotropic activity. The invention pertains to the us...
JF Habener - US
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: A is a bond or --OCH--, where the oxygen is linked to R;
Sher, Philip M，A Mathur - US
Insulinotropic hormone GLP-1 (7-36) and uses thereof
Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1(7-36) have been found to have insulinotropic activity. The invention pertains to the use of GLP-1(7-36) for the treatment of type II diabetes mellitus.
JF Habener - US
Novel thyroid receptor ligands and method
Novel thyroid receptor ligands as provided which have general formula (I) in which: R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or ...
LI YI-LIN，LIU YE，HEDFORS ASA，... - WO
Physiologically active substances
Physiologically active substances ML-236 of the formula ##SPC1## Wherein R is hydrogen atom, hydroxy group or 2-methylbutyryloxy group having cholesterol- and lipid-lowering effects in blood and liver and thus utility as hypocholesteremi...
A Endo，M Kuroda，A Terahara，... - US
Substituted pyridyl-dihydroxy-heptenoic acid and its salts
Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholester...
R Angerbauer，P Fey，W Hubsch，... - EP
Aryloxypropanolamine beta 3 adrenergic agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1.These compounds are beta 3 adrenergic receptor agonists and are useful, therefo...
PM Sher，WN Washburn，KM Poss - US
