GLP-1 ANALOGS USEFUL FOR DIABETES TREATMENT
effective analogues of GLP-1 active peptides, 7-34, 7-35, 7-36, 7-37, which have improved processing characteristics of type II diabetes. These analogs have amino acid substitutions at positions 7-10 and / or are truncated at the C-termi...
BUCKLEY Douglas I.，HABENER Joel F.，MALLORY Joanne B..，... - US
Derivatives of GLP-1 analogs
The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
Knudsen，L Bjerre - WO
GLP-1 formulations
Methods and formulations are presented that provide for a) the oral absorption of GLP-1 peptides that bind surfactants; and b) long-term storage of formulations containing these peptides. For example, a GLP-1/DSS complex is administered ...
JA Hoffmann - US
Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formula wherein R 1 , R 2 and R 2a are independently hydrogen, OH, OR 5 , alkyl, —OCHF 2 , —OCF ...
JZ Gougoutas - EP
Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-魏B activity including obesity, diabetes, inflammatory and immune diseases, and have th...
J Duan，Z Lu，DS Weinstein，... - US
N-TERMINALLY MODIFIED GLP-1 DERIVATIVES
The present invention relates to N-terminally modified derivatives of human glucagon-like peptide-1 (GLP-1) and analogues thereof having a protracted profile of action, as well as the use of such derivatives in pharmaceutical composition...
KNUDSEN Liselotte Bjerre，HUUSFELDT Per Olaf，NIELSEN Per Franklin，...
Polymer conjugates of GLP-1
Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I...
MJ Bossard，Z Fang，VX Tacey，... - US
Treatment of cardiac arrhythmias
Compositions of the invention, including compounds that bind to a receptor for a glucagon-like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an agonist, an analog (preferably an agonist analog), a derivative, ...
DR Hathaway，AD Baron - US
突变型人胰高血糖素样肽-1对神经细胞损伤的保护
目的 研究突变型人胰高血糖素样肽-1 (mutated human glucagon-like peptide-1,mGLP-1)对谷氨酸诱导的人神经母细胞瘤细胞SH-SY5Y细胞损伤的影响.方法 环磷酸腺苷(cAMP)...
张蓝，孙中伟，黄刚，... - 《中国现代应用药学》
INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula (I): the various substit...
CARSON, KENNETH GORDON，GOODWIN, NICOLE CATHLEEN，HARRISON, BRYCE ALDEN，...
