The directed ortho metalation—cross coupling symbiosis. Regioselective methodologies for biaryls and heterobiaryls. Deployment in aromatic and heteroaromatic natural product synthesis - ScienceDirect

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摘要：

In this mini-review, synthetic methods for biaryls and heterobiaryls interconnecting the directed ortho metalation (DoM) reaction with Corriu–Kumada, Negishi, Suzuki–Miyaura and, less, Stille cross coupling reactions are presented from perspectives of development of new reaction parameters (Suzuki–Miyaura: Scheme 4 , Scheme 5 , Scheme 6 , Scheme 7 ), new cross coupling partners (Corriu–Kumada: Scheme 9 , Scheme 11 ), and comprehensive evaluation ( Scheme 12 , Scheme 13 ). Recent work on the application of these protocols to indole derivatives ( Scheme 16 , Scheme 17 , Scheme 18 ), dibenzopyranones ( Scheme 19 ), aza- and isoazacoumestans ( Scheme 20 ), and kinamycin antibiotics ( Scheme 21 ) is described.

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关键词：

Directed ortho metalation Cross coupling Biaryls Heteroaromatics Natural products Synthesis

DOI：

10.1016/S0022-328X(02)01164-6

被引量：

385

年份：

2002