Association of the APC gene product with beta-catenin

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insi...

B Rubinfeld，B Souza，I Albert，... - 《Science》

Association of the APC tumor suppressor protein with catenins

Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little ...

L Su，B Vogelstein，Kinzler, K. - 《Science》

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.

A cDNA encoding the cell-cell adhesion molecule E-cadherin was transfected into highly invasive epithelial tumor cell lines of dog kidney or mouse mammary ...

KL Vleminckx，L Vakaet，MM Mareel，... - 《Cell》

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

The generation of invasiveness in transformed cells represents an essential step of tumor progression. We show here, first, that nontransformed Madin-Darby...

Behrens，J. - 《Journal of Cell Biology》

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

A novel v- erb - B -related gene, c- erb - B -2, which has been identified in the human genome 1,2 , maps to human chromosome 17 at q21 (ref. 40) and seems...

T Yamamoto，S Ikawa，T Akiyama，... - 《Nature》

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the human genome1,2, maps to human chromosome 17 at q21 (ref. 40), and seems to encod...

adash Yamamoo，Shunaro kawa，su Akyama，... - 《Nature》

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor

Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are conne...

H Hoschuetzky，H Aberle，R Kemler - 《Journal of Cell Biology》

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

Rat 3Y1 cells acquire metastatic potential when transformed with v-src, and this potential is enhanced by double transformation with v-src and v-fos (Tanig...

Matsuyoshi，N. - 《Journal of Cell Biology》

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells

The cadherin/catenin complex plays important roles in cell adhesion, signal transduction, as well as the initiation and maintenance of structural and funct...

I S Nthke，L Hinck，JR Swedlow，... - 《Journal of Cell Biology》

Hoschuetzky H, Aberle H, Kemler Rβ-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 127: 1375-1380

The cadherin/catenin complex plays important roles in cell adhesion, signal transduction, as well as the initiation and maintenance of structural and funct...

H Hoschuetzky - 《Journal of Cell Biology》