Isoxazolyl endothelin antagonists
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-...
N Murugesan，JC Barrish，Z Gu，... - US
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: A is a bond or --OCH--, where the oxygen is linked to R;
Sher, Philip M，A Mathur - US
Catecholamine surrogates useful as β3 agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds are beta three adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestina...
PTW Cheng，GS Bisacchi，AV Gavai，... - CA
Sulfonic, phosphonic or phosphiniic acid β.sub.3 agonist derivatives
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds are beta three adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestina...
COMBINATION OF AN ALDOSE REDUCTASE INHIBITOR AND A GLYCOGEN PHOSPHORYLASE INHIBITOR
not available for EP103242of corresponding document:Pharmaceutical combination compositions and methods including aldose reductase inhibitors and glycogen phosphorylase inhibitors. The compositions and methods are useful for the treatmen...
MYLARI BANAVARA LAKSHMAN，HOOVER DENNIS JAY，HULIN BERNARD，... - EP
Aryloxypropanolamine beta 3 adrenergic agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1.These compounds are beta 3 adrenergic receptor agonists and are useful, therefo...
PM Sher，WN Washburn，KM Poss - US
Treating diabetes, obesity, achalasia, gastorintestinal disorders
R 4 is --SO 3 H, --P(O 2 H)R 5 , --P(O 2 R 5' )R 5 , --PO 3 H 2 , --PO 3 HR 5' or --PO 3 (R 5' ) 2 where R 5 and R 5' are independently lower al...
PM Sher，A Mathur - US
Benzo 1,3 dioxole derivatives
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof where A is phenyl, naphthyl or dihydro- or tetrahydronaphthyl optionally substituted on the aromatic ring by one to three substituents independently selected...
PM Sher - US
Benzimidazole derivatives as 15-lo inhibitors
Benzimidazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof are MCP-1 antagonists and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders such as arthritis and tr...
JK Padia，BD Roth，BK Trivedi
Benzimidazole derivatives as 15-lo inhibitors
Benzimidazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof are MCP-1 antagonists and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders such as arthritis and tr...
Trivedi，Bharat，R Kalidas，...
