Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline- 3- carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4- tetrahydroisoquinoline with a suitably substit...

ML Hoefle，S Klutchko - US

Pyroglutamic acid derivatives and analogs

Pyroglutamic acid derivatives and analogs having the formula ##STR1## and salts thereof, wherein R is hydrogen, alkyl or diphenylmethyl;

Ondetti, Miguel A，Gordon, Eric M，Ryono, Denis E - US

Summary of Synthesis Route of Captopril

Summarize synthesis of the common methods and progress of Captopril.

H Pu，Z Yang，X Yin，... - 《Guangdong Chemical Industry》

卡托普利合成工艺路线综述

综述了常见的卡托普利合成方法以及研究进展. 查看全部>>

濮荷妹，杨志玲，殷学治，...

基于酪氨酸为端基的ACE三肽抑制剂的构效关系研究

血管紧张素转化酶(angiotensin converting enzyme, ACE)抑制剂一直是抗高血压药物研究方向的热点.而食物蛋白源ACE抑制肽因为其安全,副作用小,易吸收等特点而被广泛关...

曾威 - 《广东药学院》

Antihypertension agents

1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives of the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a phenyl-l...

T Sawayama，H Kinugasa，H Nishimura，... - US

Esters of phosphinylalkanoyl substituted prolines

Hypotensive activity is exhibited by new compounds having the formula and salts thereof wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl; R 3 i...

J Krapcho - US

Dual action inhibitors containing a pyridazinodiazepine or pyrazolodiazepine lactam ring

Compounds of the formula ##STR1## wherein X 1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and are thus useful as cardiovascular agents.

DS Karanewsky，JA Robl - US

Mercaptoacylpiperidine phosphonic acids, angiotensin converting enzyme inhibitors, hypotensive agents

New mercaptoacylpyrrolidine- and mercaptoacylpiperidine phosphonic acids which have the general formula ##STR1## are useful as angiotensin converting enzym...

EW Petrillo - US

Optically active derivatives of mercaptoisobutyric acid and methods of preparation thereof

Optically active compounds of formula ##STR1## in which R is either a HC--, (CH)C--, (CH)CO--, CHCHO--, CH--, o-NOCH--, p-NOCH-- or a p-CHCH-group, or salts or lower alkyl esters thereof. The compounds are prepared by the following seque...

JPM Houbiers - US