ENDOTHELIN ANTAGONISTS: N-[[2'-[[(4,5-DIMETHYL-3-ISOXAZOLYL) AMINO] SULFONYL]-4-(2-OXAZOLYL) [1,1'-BIPHENYL]-2-YL] METHYL]-N-3,3-TRIMETHYLBUTANAMIDE) AND S...

The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-...

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

The activity of the (R, S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist, (R,S) -2-amino-3-[5-tert-butyl-3-(phosphon...

P Wahl，C Anker，SF Traynelis，... - 《Molecular Pharmacology》

Antibacterial effect of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine onStaphylococcus aureus

The mechanism by which a new naphthoquinone derivative, the 2-hydroxy- N -(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine (INQI-E) has antibacterial...

P Bogdanov，I Albesa，NR Sperandeo，... - 《Cellular & Molecular Life Sciences》

ChemInform Abstract: Synthesis and Biological Activity of (S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic Acid (TAN-950 A) Derivatives.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem...

N.，TAMURA，Y.，... - 《Cheminform》

3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands

A novel class of central nicotinic acetylcholine receptor ligands, 3-(5-alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridine 4a-f, was synthesized. Several ...

PH Olesen，MDB Swedberg，K Rimvall - 《Bioorganic & Medicinal Chemistry》

Determination of 3-chloro- N -chloro- N -(3,4-dimethyl-5-isoxazolyl)-4-amine-1,2-naphthoquinone in presence of its degradation products using second deriva...

A rapid, selective and accurate method for stability determination of 3-chloro-N-chloro-N-(3,4-dimethyl-5-isoxazolyl)-4-amine-1,2-naphthoquinone (1b) in th...

VG Dabbene，MC Bri?Ón，MMD Bertorello - 《Analytica Chimica Acta》

Synthesis, Antiprotozoal and Cytotoxic Activities of New N-(3,4-Dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino Derivatives.

A rapid, selective and accurate method for stability determination of 3-chloro-N-chloro-N-(3,4-dimethyl-5-isoxazolyl)-4-amine-1,2-naphthoquinone (1b) in th...

N.，R.，Sperandeo，... - 《Cheminform》

ENANTIOMERS OF N-[[2'-[[(4,5-DIMETHYL-3-ISOXAZOLYL) AMINO]SULFONYL]-4-(2-OXAZOLYL)[1,1'-BIPHENYL]-2-YL]METHYL]-N,3,3-TRIMETHYLBUTANAMIDE

Endothelin antagoninst N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino] sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide surprisingly exists as separable enantiomeric atropisomers. The (+) dextrorotatory atropisom...

DE Hughes，BC Seidenberg

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-bi phenyl)- 2-...

We have previously disclosed the selective ET(A) receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide (1, BMS-193...

N Murugesan，Z Gu，S Spergel，... - 《Journal of Medicinal Chemistry》

Preparation of {[(3,4-dimethyl-5-isoxazolyl) amino] sulfonyl}-2-thiophene carboxamide - N- (2- acetyl-4,6-dimethyl-phenyl) -3

As used herein, N- (2--acetyl-4,6-dimethylphenyl) -3 - intravenous {[(3,4-dimethyl-5-isoxazolyl) amino] sulfonyl}-2-thiophenecarboxamide and oral formulati...

ジンリング チェン，リアン ラジェウスキ，アーロン スコーエネマン，...