Antihypercholesterolemic compounds
- US
Imidazole-containing inhibitors of farnesyl protein transferase
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, ...
JT Hunt - CA
Benzene, pyridine, naphtalene or benzophenone derivatives as inhibitors of squalene synthetase and protein farnesyltransferase
The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
WR Baker，SH Rosenberg，KLA Fung，... - WO
Heterozyklische Farnesyl-Protein-Transferase-Inhibitoren
The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
DV Patel，Toni Kline，CA Meyers，...
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
The invention concerns a method of extracting carotinoid dyes from pre-dried natural basic materials by means of compressed gases, such as propane and/or butane. In order to facilitate and complete the extraction process, organic entrain...
DR HEIDLAS JUERGEN，DR CULLY JAN，W Johann，... - WO
CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE
The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disor...
BAKER William R.，ROCKWAY Todd W.，DONNER B. Gregory，... - WO
SYSTEM FOR AUTOMATED HERMETIC SEALING OF CASINGS
The object of the invention is to devise a system that ensures higher quality of manufacture. One standard of quality for such systems is that the casings can be hermetically sealed, with the interior of the casings being absolutely void...
G Zeindl，F Angerer，K Schweitzer
Imidazol-enthaltende Farnesyl-Protein-Transferase-Inhibitoren
The object of the invention is to devise a system that ensures higher quality of manufacture. One standard of quality for such systems is that the casings can be hermetically sealed, with the interior of the casings being absolutely void...
JT Hunt
Cyclization; decyclization; hydrolysis; neutralization; salt formation
An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 伪-metalated N,N...
DE Butler，TV Le，TN Nanninga
ANTITUMOUR SYNERGISTIC COMPOSITION
There are provided the combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'-methansulfonyl daunorubicin and an antineoplastic topoisomerase II inhibitor in the treat...
GERONI Cristina，RIPAMONTI Marina，CARUSO Michele，... - WO
