Ligands with four pharmacologically distinct actions at the AMPA receptor are discussed. The four classes of compounds include agonists, antagonists, posit...
Programmed cell death (pcd) is a form of cell death in which the cell plays an active role in its own demise. Pcd plays a critical role in the development ...
Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and p...
In: Emerging Drugs and Targets for Alzheimer's Disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez A, editor. 2010. Ketone ...
This article highlights the latest research on the development of amyloid beta modulators for neuroprotection in Alzheimer's disease and also critically evaluates existing amyloid beta modulators as therapeutic targets in Alzheimer's dis...
and potential AMPA receptor blockers, are used for the treatment and prevention of neurodegenerative diseases, and may be particularly used for the treatment of AD (Alzheimer's disease), PD (Parkinson's disease), and other neurodegenerat...
Alzheimer's disease (AD), the most common neurodegenerative disease (NDD), is characterized by chronic neuronal cell death through progressive loss of cogn...
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly and represents a major clinical challenge in the ageing society. Neuropathol...
For more than a decade, it has been apparent that apoptosis and other forms of cell death are often controlled at one or more crucial steps involving the m...
For more than a decade, it has been apparent that apoptosis and other forms of cell death are often controlled at one or more crucial steps involving the m...
Examines the involvement of caspases in proteolytic cleavage of amyloid beta precursor protein (APP) and amyloidogenic A beta peptide formation in Alzheimer's disease. Identification of the principal sites of caspase-mediated APP proteo...
The morphology commonly known as results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade the structura...
Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their mechanistic basis remains poor...
Elevated levels of beta-Amyloid (Abeta) are present in the brains of individuals with either the sporadic or familial form of Alzheimer's disease (AD), and...
Apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative diseases and aging. ...
Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single acc...
Bcl-xL is a well characterized -suppressing molecule of the family. Bcl-xL is expressed in and adult neurons of the and may play a critical role in prevent...
Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also occur in Alzheimer's disease (AD). The degree of clinical disab...
Alzheimers disease (AD) is a multifactorial and fatal neurodegenerative disorder for which the mechanisms leading to profound neuronal loss are incompletel...
Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order e...
Senile plaques, neurofibrillary tangles, and neuronal loss are three neuropathological hallmarks of Alzheimer's disease (AD). Advanced understanding of the...
Cell death is a critically important biological process. Disruption of homeostasis, either by excessive or deficient cell death, is a hallmark of many path...
In Alzheimer's disease, cytochromec-dependent apoptosis is a crucial pathway in neuronal cell death. Although beta-amyloid (Aβ) oligomers are known to be the neurotoxins responsible for neuronal cell death, the underlying mechanisms rem...
An enormous body of evidence supports the activation of caspases may be responsible for the neurodegenerationassociated with Alzheimer's disease (AD) and for ..
Two-photon active probe to label apoptotic cells plays a significant role in biological systems. However, discrimination of live/apoptotic cells at subcellular level under microscopy remains unachieved. Here, three novel Zn颅(II) terpyri...
Two-photon active probe to label apoptotic cells plays a significant role in biological systems. However, discrimination of live/apoptotic cells at subcell...
