Synthesis and application of oxadiazines as chiral ligands for the enantioselective addition of diethylzinc to aldehydes
摘要:
A series of oxadiazines derived from l-phenylalanine bearing phenolic substituents have been synthesized in a multistep, one pot process. This process involves the reaction of a mixed anhydride with a @b-hydrazino alcohol, methanesulfonylation of the alcohol moiety, and base induced cyclization. The resultant oxadiazines were employed in the asymmetric addition of diethylzinc to aldehydes.
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DOI:
10.1016/j.tetasy.2010.09.010
年份:
2010
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