Silver Triflate Catalyzed Tandem Heterocyclization/Alkynylation of 1-((2-Tosylamino)aryl)but-2-yne-1,4-diols to 2-Alkynyl Indoles

Don't cross me! 2-Alkynyl indoles were prepared efficiently by the AgOTf-catalyzed tandem heterocyclization/alkynylation of 1-(2-tosylamino)aryl)but-2-yne-...

Srinivasa，Reddy，Mothe，... - 《Chemistry》

Silver Triflate Catalyzed Tandem Heterocyclization/Alkynylation of 1-((2-Tosylamino)aryl)but-2-yne-1,4-diols to 2-Alkynyl Indoles

Don't cross me! 2-Alkynyl indoles were prepared efficiently by the AgOTf-catalyzed tandem heterocyclization/alkynylation of 1-(2-tosylamino)aryl)but-2-yne-...

SR Mothe，P Kothandaraman，SJL Lauw，... - Chemistry - A European Journal

Palladium-catalyzed stereospecific synthesis of 2,6-disubstituted tetrahydropyrans: 1,3-chirality transfer by an intramolecular oxypalladation reaction.

PdCl2(CH3CN)2 (10 mol %) catalyzed reactions of non-3-ene-2,8-diols 1 and 2 gave 2,6-disubstituted tetrahydropyrans 3 and 4 in excellent yields with high d...

N Kawai，Lagrange, JM，M Ohmi，... - 《Journal of Organic Chemistry》

Bakers' yeast reduction of thiophenepropaenals. Enantioselective synthesis of (S)-2-methyl-1-alkanols via bakers' yeast mediated reduction of 2-methyl-3-(2...

The first total synthesis of the cytotoxic oxylipin Topsentolide B 3 has been accomplished in 15 steps with an overall yield of 24%. Starting with readily ...

HE Hoegberg，E Hedenstroem，J Faegerhag，... - 《Journal of Organic Chemistry》

Enantioselective alkynylation of a prochiral ketone catalyzed by C2-symmetric diamino diols.

C2-Symmetric diamino diols were used as chiral ligands to induce the asymmetric addition of lithium acetylides to carbonyl groups. The enantiomeric excesse...

Jiang，Biao，Feng，... - 《Tetrahedron Letters International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry》

Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold

Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4--enediol scaffold is reported. The synthetic route offers straightforward and ...

C Marian，H Rong，RF Borch - 《Tetrahedron》

TRIALKYLSILYL ETHERS OF 17ALPHA-ALKYNYLESTRA - 1,3,5(10) - TRIENE-3,17BETA-DIOLS AND 11BETA-ALKYL DERIVATIVES THEREOF

1367735 Silyl ethers of 11-alkyl-3-hydroxyestratrienes G D SEARLE & CO 6 April 1972 [7 April 1971] 15838/72 Heading C2U [Also in Division A5] Novel steroids of the formula (wherein R is H or a trialkylsilyl radical; Ris a C 1-3 alkyl rad...

E Brown，I Laos - US

Cu-mediated enantioselective C–H alkynylation of ferrocenes with chiral BINOL ligands

A wide range of Cu(II)-catalyzed C–H activation reactions have been realized since 2006, however, whether a C–H metalation mechanism similar to Pd(II)-catalyzed C–H activation reaction is operating remains an open question. To address...

X Kuang，JJ Li，T Liu，... - 《Nature Communications》

Photocatalytic Umpolung of N- and O-substituted alkenes for the synthesis of 1,2-amino alcohols and diols

We report an organophotocatalytic 1,2-oxyalkynylation of ene-carbamates and enol ethers using Ethynyl BenziodoXolones (EBXs). 1-Alkynyl-1,2-amino alcohols and diols were obtained in up to 89% yield. Photocatalytic formation of radical ca...

SGE Amos，S Nicolai，J Waser - 《Chemical Science》