Organocatalytic Asymmetric Vinylogous Michael Addition of 3-(2-Oxoindolin-3-ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona-Based Squaramide
摘要:
The highly efficient asymmetric vinylogous Michael addition of 3-(2-oxoindolin-3-ylidene)butanoates to nitroalkenes, catalyzed by a cinchona-based squaramide, is described. The enantioselectivity (up to 99% ee) and diastereoselectivity (>20:1d.r.) of the reaction is excellent.
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DOI:
10.1002/ajoc.201500111
年份:
2015
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