Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property.
摘要：
Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.
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关键词：
CELL-CELL ADHESION RING-CLOSING METATHESIS LYMPHOMA U937 CELLS ABSOLUTE STEREOSTRUCTURES COMMON PHARMACOPHORE DRUG-RESISTANCE EPOTHILONES INHIBITORS STRATEGY POTENT
DOI：
10.1021/ol061922v
被引量：
年份：
2006
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