Transdermal therapeutic system with fentanyl or related substances
公开/公告号：
US20040234584 A1
公开/公告日期：
Dec 28, 2005
被引量：
摘要：
本发明涉及一种由活性物质不渗透的背层,至少含有一种芬太尼或芬太尼类似物的活性物质的基于聚丙烯酸酯的基质层和使用前移除的保护层的透皮治疗体系(TTS),其特征在于,所述聚丙烯酸酯是自粘性的且不具有羧基,其对于芬太尼具有3-20重量%的饱和溶解度,优选饱和溶解度为4-12重量%,尤其优选饱和溶解度为5-10重量%,并且活性物质层中所包埋的活性物质至少80重量%以分子分散液的溶解形式存在. The present invention relates to an active substance impermeable backing layer, at least based on polyacrylate containing matrix layer and the protective layer is removed prior to use of the transdermal fentanyl or fentanyl analogues treating one active substance System (TTS), characterized in that the polyacrylate is self-adhesive and not having a carboxyl group, which has 3-20% by weight for fentanyl saturation solubility, preferably 4-12 wt% of the saturated solubility, particularly preferably 5-10% by weight of the saturation solubility, and the active material layer embedded in the active substance of at least 80 wt.% in dissolved form in the presence of molecular dispersion.
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