Peptides and compounds that bind to the IL-1 receptor
申请(专利)号：
IL19950112529
申请日期：
1995-02-02
公开/公告号：
IL112529D0
公开/公告日期：
1995-05-26
申请(专利权)人：
AFFYMAX TECHNOLOGIES N.V.
被引量：
摘要：
Peptides that bind to the interleukin-1 type I receptor (IL- 1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 2) where Z. sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where (SEQ ID NO: 1) Z. sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z. sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub. 29 Z.sub.30 L (SEQ ID NO: 313) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub. 28 is S or W; Z. sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.
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