Objective To assess the association of cognitive dysfunction and depression with serum antibodies to N -methyl- D -aspartate (NMDA) receptor (anti-NR2) and...
Objective Cognitive dysfunction is common in both systemic lupus erythematosus (SLE) and primary Sj枚gren's syndrome (SS). Antibodies against the NR2 subty...
Background:Self-reactive antibodies are a characteristic of systemic lupus erythematosus [SLE]. These autoantibodies may attack any organ or tissue in the ...
Background Anti‐ DNA /N‐methyl‐D‐aspartate receptor 2 ( NR 2) antibodies (anti‐ DNA / NR 2 antibodies) are a subset of anti‐ DNA autoantibodies that ...
Background Anti‐ DNA /N‐methyl‐D‐aspartate receptor 2 ( NR 2) antibodies (anti‐ DNA / NR 2 antibodies) are a subset of anti‐ DNA autoantibodies that ...
In systemic lupus erythematosus, antibodies against double-stranded DNA are a major contributor to renal disease. We have previously demonstrated that the ...
in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N-methyl-D-aspartate (NMDA) receptor types NR2a or NR2b...
Anti-DNA antibodies can also crossreact with the anti-N-methyl-D-aspartate receptor and may cause cognitive dysfunction or depression in lupus patients [1...
The aim of this study is to establish a detection method for anti-N-methyl-d-aspartate receptor subunit 2A (NR2A) antibody and to evaluate the relationship...
In contrast to the objective of most clinical trials, which is to demonstrate superiority of an experimental treatment over a standard or placebo, the aim ...
In systemic lupus erythematosus, antibodies against double-stranded DNA are a major contributor to renal disease. We have previously demonstrated that the ...
Chronic antidepressant treatment results in adaptation of the NMDA receptor complex in the rodent cortex. This adaptation consists of a reduction in the po...
Objective: The San Antonio Lupus Study of Neuropsychiatric Disease is a longitudinal study designed to characterize the spectrum of and important risk fact...
The psychotomimetic properties of NMDA glutamate receptor antagonists suggest there may be disease related changes of this receptor in schizophrenia. Using...
OBJECTIVE: To prospectively analyze the association between changes in cognitive function and circulating anticardiolipin antibodies (aCL) over a period of...
Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS vascular disease or inflammation. SLE patients produce anti-DNA ant...
Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS vascular disease or inflammation. SLE patients produce anti-DNA ant...
We administered a battery of neuropsychological tests to 62 female patients with systemic lupus erythematosus (SLE), 12 female patients with rheumatoid arthritis (RA), and 35 normal control subjects. By applying objective decision rules ...
Multiple reliable and valid disease activities indices exist and have been used successfully in longitudinal studies. However, the definition of flare, usi...
Objective To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis. Methods Analysis of clinical features, neuropa...
OBJECTIVES: To develop recommendations for the diagnosis, prevention and treatment of neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations....
Neuropsychiatric systemic lupus erythematosus, which often entails cognitive disturbances and memory loss, has become a major complication for lupus patien...
The year 2007 marks the 50th anniversary of the identification of antibodies to double-stranded (ds) DNA. Whilst widely regarded as synonymous with patient...
Objectives To develop recommendations for the diagnosis, prevention and treatment of neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations.
We propose that the normal immunocompetent B cell repertoire is replete with B cells making antibodies that recognize brain antigens. Although B cells that...
The urgent need for lupus biomarkers was demonstrated in September 2011 during a Workshop sponsored by the Food and Drug Administration: Potential Biomarke...
The urgent need for lupus biomarkers was demonstrated in September 2011 during a Workshop sponsored by the Food and Drug Administration: Potential Biomarke...
