摘要：

Objective To investigate the clinical effect and predictive value of AI,MVD of tumor tissue and SCC level in the serum in patients with bulky and locally advanced cervical cancer treated by NACT. Methods Between March 2000 and March 2008,86 women with primary cervical cancer of FIGO stage Ib2~Ⅱb in the Affiliated Jiangmen Hospital of Sun Yat-Sen University were treated by NACT. They were divided into the effective group and non-effective group according to the clinical response to NACT. AI and MVD of the carcinoma and serum SCC level in patients with squamous cell carcinoma of the two groups before and after NACT were evaluated and the relationship between the changes of the three parameters and the clinical results were analyzed. Results In effective group,the mean AI value after NACT was significantly increased than that before NACT (P=0.011),while serum SCC level decreased significantly (P=0.039). A little decrease was found in MVD but without statistic significance (P=0.071). Before NACT,the mean AI was significantly higher in effective group than non-effective one (P=0.027) but no statistic significance was found in MVD and the serum SCC level between two groups (P=0.87,P=0.357). In the squamous cell carcinoma,the reduction percentage in serum SCC level after first NACT in effective group was significantly increased than non-effective one (P0.001). AI higher than 1.0 before NACT and the reduction percentage in serum SCC level of the squamous cell carcinoma after first NACT higher than 50% index were associated with a better clinical effect (P=0.042,P=0.021). Conclusion AI and serum SCC level are useful parameters in evaluating NACT response. The AI level before NACT and the reduction percentage of serum SCC level after first NACT in the squamous cell carcinoma are valuable of predicting the response to NACT.

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