Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma.
摘要：
Members of the bcl-2 gene family play a central role in regulating the relative sensitivity and resistance of cells to a wide variety of apoptotic stimuli. The first member of this multigene family , bcl-2 , was discovered by virtue of its involvement in the t(14;18) chromosomal translocations commonly found in non-Hodgkin's lymphomas [1–4]. Deregulation of the bcl-2 gene either by translocations in B-cell lymphomas or through other mechanisms in several other types of cancer, including acute and chronic leukemias, contributes to neoplastic cell expansion by prolonging cell survival rather than by accelerating rates of cell division [5–8]. The Bcl-2 protein also can protect tumor cells from apoptosis induced by radiation and nearly all cytotoxic anticancer drugs [9–12], thus potentially contributing to treatment failures in patients with cancer [13–16]. Several additional homologues of bcl-2 have recently been discovered in humans and other mammals, revealing the presence of a multigene family [17–20]. Moreover, homologues of bcl-2 have been discovered in some DNA viruses, including Epstein-Barr virus (EBV), which plays a significant role in the pathogenesis of some types of non-Hodgkin's lymphomas and Hodgkin's disease [21]. Interestingly, some members of the bcl-2 gene family function as inhibitors of cell death, similar to bcl-2 , whereas others are promoters of apoptosis that oppose the actions of the Bcl-2 protein.
展开
DOI：
10.1007/978-1-4613-1261-1_3
被引量：
年份：
1996
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
