COMPOSITIONS COMPRISING NANOPARTICULATE NAPROXEN AND CONTROLLED RELEASE HYDROCODONE

阅读量:

23

申请(专利)号:

US11768154

申请日期:

20070625

公开/公告号:

US20080113025A1

公开/公告日期:

20080515

申请(专利权)人:

John G. Devane Paul Stark Niall Fanning Gurvinder Singh Rekhi Scott A. Jenkins Gary Liversidge

发明人:

JG DevaneP StarkN FanningGS RekhiSA JenkinsG Liversidge

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被引量:

227

摘要:

The invention relates to a compositions comprising a nanoparticulate naproxen composition in combination with a multiparticulate modified release hydrocodone composition that, upon administration to a patient, delivers a hydrocodone in a bimodal or multimodal manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component; the first component comprising a first population of hydrocodone-comprising particles and the at least one subsequent component comprising a second population of hydrocodone-comprising particles, wherein the combination of the components exhibit a bimodal or multimodal release profile. The invention also relates to a solid oral dosage form comprising such a combination composition.

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2010
被引量:24

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