Multiparticulate modified release composition
申请日期：
05/07/2001
公开/公告号：
US6730325
申请(专利权)人：
CHURCH MARLA J ELAN CORP PLC DEVANE JOHN G FANNING NIALL M M STARK PAUL
国省代号：
WO
被引量：
摘要：
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the immediate release component comprising a first population of active ingredient containing particles and the modified release component comprising a second population of active ingredient containing particles coated with a controlled release coating; wherein the combination of the immediate release and modified release components in operation deliver the active ingredient in a pulsed or a bimodal manner. The invention also relates to a solid oral dosage form containing such a multiparticulate modified release composition. The plasma profile achieved by the multiparticulate modified release composition is advantageous in reducing patient tolerance to the active ingredient and in increasing patient compliance by reducing dosage frequency.
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