Pattern triplications following genetic ablation on the wing ofDrosophila
摘要：
The effects of polyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous for ph , sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the wing has special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8–16 cells affect the polarity of the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellular communication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerative growth, and reorganize into a new pattern. The pleiotropic phenotypes of ph mutants are explained according to a common hypothesis about ph + function.
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DOI：
10.1007/BF02447741
被引量：
年份：
1989
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