Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prostate Cancer

The expression level of the androgen receptor (AR) gene in androgen-dependent and -independent prostate cancer was determined by using real-time quantitati...

MJ Linja，KJ Savinainen，Saramki OR，... - 《Cancer Research》

Oncogenic Mutations of PIK3CA in Human Cancers

Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in human cancers,...

Y Samuels，VE Velculescu - 《Cell Cycle》

Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study.

BackgroundIntravenous injection is the standard administration route of bortezomib; however, subcutaneous administration is an important alternative. We co...

P Moreau，H Pylypenko，S Grosicki，... - 《Lancet Oncology》

Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prostate Cancer Advances in Brief Amplification and Overexpression of Andr...

BackgroundIntravenous injection is the standard administration route of bortezomib; however, subcutaneous administration is an important alternative. We co...

MJ Linja，KJ Savinainen，OR Saramäki，...

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with >= 50% of tumours expressing the BRAF(V600E) oncoprotein(1,2...

MD Thakur，F Salangsang，AS Landman，... - 《Nature》

Prion-like transmission of protein aggregates in neurodegenerative diseases.

Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that ...

P Brundin，R Melki，R Kopito - 《Nature Reviews Molecular Cell Biology》

Trends in the exploitation of novel drug targets

The discovery and exploitation of new drug targets is a key focus for both the pharmaceutical industry and academic biomedical research. To provide an insi...

M Rask-Andersen，MS Almén，HB Schi?Th - 《Nature Reviews Drug Discovery》

Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system.

Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the ...

Z Culig，J Hoffmann，M Erdel，... - 《Br J Cancer》

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity

Lapatinib is a human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitor (TKI) that has clinical activity in HER2-amplified breast cancer. ...

M Scaltriti，C Verma，M Guzman，... - 《Oncogene》

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.

AR gene expression in CRPC is increased by an enhancer in the second intron This enhancer is repressed by AR at high androgen levels through LSD1 recruitm...

C Cai，H He，S Chen，... - 《Cancer Cell》