The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus.
摘要：
We hybridized neoplastic cells from a patient with chronic lymphocytic leukemia of the B-cell type, which carried a reciprocal chromosomal translocation between chromosomes 11 (q13) and 14 (q32) with mouse plasmacytoma cells. The hybrid cells were studied for the presence, rearrangement, and expression of the human immunoglobulin μ chain locus. The results indicate that the expressed μ chain gene is located on the normal chromosome 14, whereas the 14q+translocation chromosome carries the excluded immunoglobulin constant (C) region μ chain allele (Cμ) but does not contain variable (V) region heavy chain genes (VH). Since we found that the heavy chain joining region DNA (JH) of the excluded μ chain gene is on the 14q+chromosome, we can conclude that the chromosomal break observed in the leukemic cells occurred in a chromosomal region within or 5′of the JHregion. With these results, it is logical to postulate that a gene, for which we suggest the name bcl-1, is located on band q13 of chromosome 11 and is activated by its translocation into close proximity with the rearranged heavy chain locus on chromosome 14q+, contributing to the neoplastic transformation of the B cells with the t(11;14) chromosomal translocation.
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关键词：
Genetics Specific Chromosomal Translocations B-Cell Lymphomas and Leukemias Gene Mapping Gene bcl-1
DOI：
10.1073/pnas.81.13.4144
被引量：
年份：
1984
万方医学
万方医学
掌桥科研
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