Tobacco smoke carcinogens and lung cancer.

The complexity of tobacco smoke leads to some confusion about the mechanisms by which it causes lung cancer. Among the multiple components of tobacco smoke...

S，S，Hecht - 《Journal of the National Cancer Institute》

Tobacco Smoke Carcinogens and Lung Cancer

Cigarette smoking is the major cause of lung cancer, the largest cancer killer in the world. This chapter discusses the role of cigarette smoke carcinogens...

SS Hecht - Humana Press

Small-airway obstruction and emphysema in chronic obstructive pulmonary disease.

BACKGROUND: The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm in diameter). We wanted to determine wh...

McDonough, John E.，R Yuan，M Suzuki，... - 《N Engl J Med》

Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults.

BACKGROUND: Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associat...

R Vassallo，JH Ryu，DR Schroeder，... - 《N Engl J Med》

Definition, epidemiology and natural history of COPD

Chronic obstructive pulmonary disease (COPD) is the fifth cause of morbidity and mortality in the developed world and represents a substantial economic and...

G Viegi，F Pistelli，DL Sherrill，... - 《European Respiratory Journal》

Eosinophil infiltration and degranulation in normal human tissue

Localization of eosinophil granule major basic protein by immunofluorescence permits recognition of both eosinophil infiltration and degranulation. Over th...

M Kato，GM Kephart，NJ Talley，... - 《Anatomical Record》

Eosinophil Infiltration and Degranulation in Normal Human Tissues: Evidence for Eosinophil Degranulation in Normal Gastrointestinal Tract

Eosinophils play an important role in the pathogenesis of inflammatory diseases such as bronchial asthma and host immunity to parasitic infections. Deposit...

M Kato，GM Kephart，A Morikawa，... - 《Int Arch Allergy Immunol》

Pathogenesis of Chronic Obstructive Pulmonary Disease

The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a number of injurious processes, including an abnormal inflammatory response i...

W Macnee - 《Clinics in Chest Medicine》

Acute interstitial pneumonia: thin-section CT findings in 36 patients.

To characterize the computed tomographic (CT) findings of acute interstitial pneumonia and to correlate the pattern and the extent of abnormalities with th...

T Johkoh，NL Müller，H Taniguchi，... - 《Radiology》

Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients.

To assess the thin-section computed tomographic (CT) findings of lymphocytic interstitial pneumonia. The study included 22 patients (five men, 17 women; ag...

T Johkoh，NL Müller，HA Pickford，... - 《Radiology》