A series of α-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides ...
Explores the potential of alpha-halogenated acetophenones as a novel class of potent, covalent protein tyrosine phosphatases (PTP) inhibitors. Phosphoryla...
We tested several PTP inhibitors to see if they would affect Chaetopterus pergamentaceus oocytes. Oocytes treated with alpha-bromo-4-hydroxy-acetophenone;...
A series of 伪-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides ...
Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Here, the crystal structure of a human DSP,...
Numerous protein tyrosine phosphatases have been characterized that are expressed by hematopoietic-derived cells. CD45, a transmembrane protein tyrosine ph...
Numerous protein tyrosine phosphatases have been characterized that are expressed by hematopoietic-derived cells. CD45, a transmembrane protein tyrosine ph...
Little is known about the functional connectivity between astrocytes in the CNS. To explore this issue we photo-released glutamate onto a single astrocyte ...
Cysteine aspartyl protease-3 (caspase-3) is a mediator of apoptosis and a therapeutic target for a wide range of diseases. Using a dynamic combinatorial te...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem...
[reaction: see text] The palladium-catalyzed reaction of aryl iodides with acetic anhydride provides a straightforward and experimentally simple carbon mon...
Hydrogen bonding plays a major role in the tight binding of the FMN cofactor in flavodoxins. The present NMR investigation provides direct experimental evi...
Diabetes is a prevalent disease which effects over 150 million people worldwide and there is a great medical need for new therapeutic agents to treat it. I...
Despite dramatic advances in adjuvant therapies, patients with malignant glioma face a bleak prognosis. Because many adjuvant therapies seek to induce glio...
Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways by controlling the level of tyrosine phosphorylation. The pas...
Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however,...
