Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline- 3- carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4- tetrahydroisoquinoline with a suitably substit...

ML Hoefle，S Klutchko - US

Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids

Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.

J Krapcho，PC Wade - US

Hypotensive agents

Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the pharmaceutically acceptable salts thereof are produced by couplin...

ML Hoefle，S Klutchko - US

Compounds containing a fused multiple ring lactam

Compounds of the formula ##STR1## wherein A is ##STR2## are useful as ACE and NEP inhibitors and those wherein A is ##STR3## are useful as ACE inhibitors. Methods of preparation and intermediates are also disclosed.

Jeffrey A. Robl

N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives

Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substituted on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3- phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiote...

Dong H. Kim，Ronald J. McCaully

PROLINE DERIVATIVES

H-284a CANABSTRACT\nThe invention relates to the stereospecific\nsynthesis of angiotensin converting enzyme (ACE)\ninhibitors having the formula:wherein R1 is lower alkyl and R4 and R5 are both\nhydrogen or together with the carbons to w...

ROGER CROSSLEY

Summary of Synthesis Route of Captopril

Summarize synthesis of the common methods and progress of Captopril.

H Pu，Z Yang，X Yin，... - 《Guangdong Chemical Industry》

基于酪氨酸为端基的ACE三肽抑制剂的构效关系研究

血管紧张素转化酶(angiotensin converting enzyme, ACE)抑制剂一直是抗高血压药物研究方向的热点.而食物蛋白源ACE抑制肽因为其安全,副作用小,易吸收等特点而被广泛关...

曾威 - 《广东药学院》

PYRROLIDINE AND THIAZOLE DERIVATIVES WITH ANTIBACTERIAL AND METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES

A method of treatment of bacterial infections in humans or animals with comprises administering, in combination with a beta-lactam antibiotic, a therapeuti...

Gilpin，Martin，P Leonard，...

Methods for treating cardiovascular disorder

A method of treatment of bacterial infections in humans or animals with comprises administering, in combination with a beta-lactam antibiotic, a therapeuti...

W Limited