An emerging body of evidence suggests that an increased prevalence of insulin abnormalities and insulin resistance in Alzheimer's disease may contribute to...
Although increased lifespan is associated with reduced insulin signaling, insulin signaling is essential for neuronal development and survival. Insulin res...
Insulin resistance (reduced ability of insulin to stimulate glucose utilization) is common in North American and Europe, where as many as one third of all ...
The ability of the brain to locally augment glucose delivery and blood flow during neuronal activation, termed neurometabolic and neurovascular coupling, r...
Peroxisome proliferator activated receptors (PPARs) are well studied for their role of peripheral metabolism, but they also may be involved in the pathogen...
The ability of the brain to locally augment glucose delivery and blood flow during neuronal activation, termed neurometabolic and neurovascular coupling, r...
Type II diabetes is a polygenic disorder, characterized in most cases by early onset of resistance to the action of insulin. Insulin sensitizers belonging ...
Background The rising numbers of people at risk for development of Alzheimer's disease (AD), and a greater understanding of the disease process, have focused attention on preventing or delaying the onset of AD symptoms. Objective: Design...
Discusses the influence of oxidative stress on neurodegeneration. Generation of reactive oxygen species in normal cells; Disadvantage of the misregulation ...
Epidemiological evidence suggests that moderate consumption of red wine reduces the incidence of Alzheimer disease (AD). To study the protective effects of...
Mild-to-moderate AD patients were randomized to placebo or rosiglitazone (RSG) 2, 4 or 8 mg. Primary end points at Week 24 were mean change from baseline i...
The apolipoprotein E (APOE) 4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE 4 allele markedly inc...
Neuritic plaques in the brain of Alzheimer's disease patients are characterized by beta-amyloid deposits associated with a glia-mediated inflammatory respo...
Until recently, the brain was studied almost exclusively by neuroscientists and the immune system by immunologists, fuelling the notion that these systems ...
Objective: To assess the association of metabolic syndrome (MetS) with Alzheimer disease (AD).Methods: The authors derived subjects from a population-bas...
Clinical studies suggest that agonists at peroxisome proliferator-activated receptor gamma (PPARγ) may exert beneficial effects in patients with mild-to-m...
The finding that activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) suppresses inflammation in peripheral macrophages and in models...
BACKGROUND This study was proposed to compare the efficacy and safety of GTM-1, Rapamycin (Rap), and Carbamazepine (CBZ) in managing Alzheimer disease (AD)...
Combination therapy approaches may be necessary to address the many facets of pathologic change in the brain in Alzheimer's disease (AD). The drugs leptin ...
Pioglitazone may have potential benefits as an alternative therapeutic treatment for patients with Alzheimer's disease (AD), particularly in individuals th...
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia. AD is characterized by brain presence of senile plaques, which are formed by aggregates of A尾 peptide and neurofibrillary tangles (NFTs), for...
We utilized a cell-level approach to examine glycolytic pathways in the DLPFC of subjects with schizophrenia (n?=?16) and control (n?=?16) and found decrea...
We utilized a cell-level approach to examine glycolytic pathways in the DLPFC of subjects with schizophrenia (n=16) and control (n=16) and found decreased ...
The present study examined the effects of honokiol on amyloid- generation and neuroinflammation. Therefore, honokiol may be a potential therapeutic approach for Alzheimer's disease. Copyright 2018 by The American Society for Pharmacolo...
These results identify FGF14 as a potential PPARγ-sensitive target controlling Aβ-induced dysfunctions of neuronal activity in the DG underlying memory l...
