Effects of Carbopol 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

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作者：

Y Zheng，WQ Ouyang，YP Wei，SF Syed，CS Hao，BZ Wang，YH Shang

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摘要：

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 µg/cm2) > NG1 (213 µg/cm2) > NG2 (123 µg/cm2) > NG3 (74.3 µg/cm2). The flux rates of citral decreased in the order NE (1,026 µg/cm2) > NG1 (1,021 µg/cm2) > NG2 (541 µg/cm2) > NG3 (353 µg/cm2). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE (P Keywords: nanoemulsion, nanoemulsion gel, Carbopol 934 proportion, topical drug delivery, transdermal drug delivery

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关键词：

nanoemulsion nanoemulsion gel Carbopol 934 proportion topical drug delivery transdermal drug delivery

DOI：

10.2147/IJN.S119286

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年份：

2016