Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin).
Excessive intake of dietary fat contributes to the development and maintenance of both obesity and hyperlipidemia. Inhibition of gastrointestinal lipases c...
JB Hauptman，FS Jeunet，D Hartmann - 《American Journal of Clinical Nutrition》
LEUCINE DERIVATIVES
Novel compounds of the formula ##STR1## wherein A signifies the group ##STR2## or --(CH.sub.2).sub.5 --, which inhibit pancreas lipase and can be used for the control or prevention of obesity and hyperlipaemia, are disclosed. The invent...
P Hadvary，E Hochuli，E Kupfer，... - US
Dictionary of Antibiotics and Related Substances
Bacterial and parasitic diseases are the second leading cause of death worldwide, according to a report by the London School of Economics. Due to the emerg...
DJ Payne - Chapman and Hall,
Inhibits carbohydrate metabolism
An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of...
M Otani，T Saito，S Satoi，... - US
Novel polypeptides with an α-amylase-inhibiting action, a process for their preparation, their use and pharmaceutical products
Cyclic polypeptides of the formula I ##STR1## in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an α-amylase-inhibiting action.
L Vertesy，D Tripier，H Ritzel - US
PHYSIOLOGICALLY ACTIVE SUBSTANCE M4582 AND PRODUCTION THEREOF
PURPOSE:To provide the title substance useful as a remedy for the cataract, etc., of diabetic complications and having an inhibitory activity against aldose reductase, by culturing a physiologically active substance M4582-producing bacte...
YAGINUMA SATOSHI，ASAHI TERU，TAKADA MASAKI，...
Antiobesity and fat-reducing agents
An antiobesity and fat-reducing composition and method of treating obesity in an animal, including human, in need of such treatment as well as a feed compo...
T Nakatsu，Z Chen
Anticaries agents, antidiaretic agents, antilipemic agents, dietetics, antilipolytic agents
This invention relates to Trestatin A, Trestatin B and Trestatin C salts thereof and mixtures thereof as well as compositions containing at least one of th...
Y Suhara，K Ogawa，K Yokose，... - US
NEW PHOSPHONATE DERIVATIVES AS LIPASE AGENTS INHIBITING
Compounds of the formula R-(R<2>=)P(X)-OR<1> wherein R is an optionally substituted alkyl group, R<1> is an optionally substituted alkyl group or an optionally substituted phenyl group, R<2> is oxygen or sulphur, and X is a leaving group...
FREDRIK BJORKLING，SHAMKANT ANANT PATKAR
Amino sugar derivatives containing trehalose
This invention relates to Trestatin A, Trestatin B and Trestatin C salts thereof and mixtures thereof as well as compositions containing at least one of the Trestatins A, B or C or a salt thereof. These compositions are useful for the i...
Y Suhara，K Ogawa，K Yokose，...
